Associations of maternal and infant metabolite profiles with foetal growth and the odds of adverse birth outcomes.

ABSTRACT:

Background

Adaptations in maternal and foetal metabolic pathways may predispose to altered foetal growth and adverse birth outcomes.

Objective

To assess the associations of maternal early-pregnancy metabolite profiles and infant metabolite profiles at birth with foetal growth from first trimester onwards and the odds of adverse birth outcomes.

Methods

In a prospective population-based cohort among 976 Dutch pregnant women and their children, serum concentrations of amino acids, non-esterified fatty acids (NEFA), phospholipids (PL) and carnitines in maternal early-pregnancy blood and in cord blood were obtained by liquid-chromatography tandem mass spectrometry. Information on foetal growth was available from first trimester onwards.

Results

After false discovery

SUBMITTER: Voerman E 

PROVIDER: S-EPMC9285592 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature