Tape strips from early-onset pediatric atopic dermatitis highlight disease abnormalities in nonlesional skin.

ABSTRACT:

Background

Skin biopsies promote our understanding of atopic dermatitis/AD pathomechanisms in infants/toddlers with early-onset AD, but are not feasible in pediatric populations. Tape strips are an emerging, minimally invasive alternative, but global transcriptomic profiling in early pediatric AD is lacking. We aimed to provide global lesional and nonlesional skin profiles of infants/toddlers with recent-onset, moderate-to-severe AD using tape strips.

Methods

Sixteen tape strips were collected for RNA-seq profiling from 19 infants/toddlers (<5 years old; lesional and nonlesional) with early-onset moderate-to-severe AD (≤6 months) and 17 healthy controls.

Results

We identified 1829 differentially expressed genes/DEGs in lesional AD and 662 DEGs in nonlesional AD, vs he

SUBMITTER: Pavel AB 

PROVIDER: S-EPMC9285647 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature