Real-Time Non-Invasive Monitoring of Short-Chain Fatty Acids in Exhaled Breath.

ABSTRACT: Short-chain fatty acids (SCFAs) are important metabolites produced by the gut microbiome as a result of the fermentation of non-digestible polysaccharides. The most abundant SCFAs are acetic acid, propionic acid, and butyric acid which make up 95% of this group of metabolites in the gut. Whilst conventional analysis SCFAs is done using either blood or fecal samples, SCFAs can also be detected in exhaled breath using proton transfer reaction-time-of-flight- mass spectrometry (PTR-ToF-MS) using H₃O⁺ for ionization. However, no investigation has been performed to characterize the reactions of SCFAs with H₃O⁺ and with other reagent ions, such as O₂ ⁺ and NO⁺. Gas-phase samples of acetic acid, propionic acid, and butyr

SUBMITTER: Meurs J 

PROVIDER: S-EPMC9285658 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature