Mechanistic characterization of endothelial sprouting mediated by pro-angiogenic signaling.

ABSTRACT:

Objective

We aim to quantitatively characterize the crosstalk between VEGF- and FGF-mediated angiogenic signaling and endothelial sprouting, to gain mechanistic insights and identify novel therapeutic strategies.

Methods

We constructed an experimentally validated hybrid agent-based mathematical model that characterizes endothelial sprouting driven by FGF- and VEGF-mediated signaling. We predicted the total sprout length, number of sprouts, and average length by the mono- and co-stimulation of FGF and VEGF.

Results

The experimentally fitted and validated model predicts that FGF induces stronger angiogenic responses in the long-term compared with VEGF stimulation. Also, FGF plays a dominant role in the combination effects in endothelial sprouting. Moreover, the model su

SUBMITTER: Song M 

PROVIDER: S-EPMC9285777 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature