Contextual generalization of social stress learning is modulated by orexin receptors in basolateral amygdala.

ABSTRACT: Fear-associated memories and behavior are often expressed in contexts/environments distinctively different from those in which they are created. This generalization process contributes to psychological disorders, particularly PTSD. Stress-related neurocircuits in the basolateral amygdala (BLA) receive inputs from hypothalamic orexin (Orx) neurons, which mediate neuronal activity by targeting orexin 1 (Orx₁R) and orexin 2 (Orx₂R) receptors via opposing functions. In BLA, inhibition of Orx₁R or activation of Orx₂R ameliorate stress responsiveness and behavior. We discovered that most Orx₁R⁺ cells also express CamKIIα, while a majority of Orx₂R⁺ cells are colocalized with GAD67. Further, Orx₁R g

SUBMITTER: Yaeger JDW 

PROVIDER: S-EPMC9285878 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature