PBK Model-Based Prediction of Intestinal Microbial and Host Metabolism of Zearalenone and Consequences for its Estrogenicity.

ABSTRACT:

Scope

The aim of the present study is to develop physiologically-based kinetic (PBK) models for rat and human that include intestinal microbial and hepatic metabolism of zearalenone (ZEN) in order to predict systemic concentrations of ZEN and to obtain insight in the contribution of metabolism by the intestinal microbiota to the overall metabolism of ZEN.

Methods and results

In vitro derived kinetic parameters, apparent maximum velocities (V_max ) and Michaelis-Menten constants (K_m ) for liver and intestinal microbial metabolism of ZEN are included in the PBK models. The models include a sub-model for the metabolite, α-zearalenol (α-ZEL), a metabolite known to be 60-times more potent as an estrogen than ZEN. Integrating intestinal microbial ZEN metabolis

SUBMITTER: Mendez-Catala DM 

PROVIDER: S-EPMC9285883 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature