The WNT/β-catenin dependent transcription: A tissue-specific business.

ABSTRACT: β-catenin-mediated Wnt signaling is an ancient cell-communication pathway in which β-catenin drives the expression of certain genes as a consequence of the trigger given by extracellular WNT molecules. The events occurring from signal to transcription are evolutionarily conserved, and their final output orchestrates countless processes during embryonic development and tissue homeostasis. Importantly, a dysfunctional Wnt/β-catenin pathway causes developmental malformations, and its aberrant activation is the root of several types of cancer. A rich literature describes the multitude of nuclear players that cooperate with β-catenin to generate a transcriptional program. However, a unified theory of how β-catenin drives target gene expression is still missing. We will discuss two types of β-ca

SUBMITTER: Soderholm S 

PROVIDER: S-EPMC9285942 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature