Revisiting the relationship between (Pro)Renin receptor and the intrarenal RAS: focus on the soluble receptor.

ABSTRACT:

Purpose of review

The (pro)renin receptor (PRR), also termed as ATPase H+ transporting accessory protein 2 (ATP6AP2), was originally cloned as a specific receptor for prorenin and renin [together called (pro)renin]. Given the wide tissue distribution of PRR, PRR was further postulated to act as a regulator of tissue renin. However, assigning a physiological role of PRR within the renin-angiotensin system (RAS) has been challenging largely due to its pleotropic functions in regulation of embryogenesis, autophagy, and H+ transport. The current review will summarize recent advances in understanding the roles of sPPR within the intrarenal RAS as well as those outside this local system.

Recent findings

Site-1 protease (S1P) is a predominant source of sPPR at least in the kidney.

SUBMITTER: Yang T 

PROVIDER: S-EPMC9286065 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature