Left atrial remodeling in mitral regurgitation: A combined experimental-computational study.

ABSTRACT:

Aims

Progressive changes to left atrial (LA) structure and function following mitral regurgitation (MR) remain incompletely understood. This study aimed to demonstrate potential underlying mechanisms using experimental canine models and computer simulations.

Methods

A canine model of MR was created by cauterization of mitral chordae followed by radiofrequency ablation-induced left bundle-branch block (LBBB) after 4 weeks (MR-LBBB group). Animals with LBBB alone served as control. Echocardiography was performed at baseline, acutely after MR induction, and at 4 and 20 weeks, and correlated with histology and computer simulations.

Results

Acute MR augmented LA reservoir and contractile strain (40±4 to 53±6% and -11±5 to -22±9% respectively, p<0.05). LA fractional area ch

SUBMITTER: Bouwmeester S 

PROVIDER: S-EPMC9286246 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature