Stimulus presentation can enhance spiking irregularity across subcortical and cortical regions.

ABSTRACT: Stimulus presentation is believed to quench neural response variability as measured by fano-factor (FF). However, the relative contributions of within-trial spike irregularity and trial-to-trial rate variability to FF fluctuations have remained elusive. Here, we introduce a principled approach for accurate estimation of spiking irregularity and rate variability in time for doubly stochastic point processes. Consistent with previous evidence, analysis showed stimulus-induced reduction in rate variability across multiple cortical and subcortical areas. However, unlike what was previously thought, spiking irregularity, was not constant in time but could be enhanced due to factors such as bursting abating the quench in the post-stimulus FF. Simulations confirmed plausibility of a time varying

SUBMITTER: Fayaz S 

PROVIDER: S-EPMC9286274 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature