Comparison of approaches for source attribution of ESBL-producing Escherichia coli in Germany.

ABSTRACT: Extended-spectrum beta-lactamase (ESBL)-producing Escherichia (E.) coli have been widely described as the cause of treatment failures in humans around the world. The origin of human infections with these microorganisms is discussed controversially and in most cases hard to identify. Since they pose a relevant risk to human health, it becomes crucial to understand their sources and the transmission pathways. In this study, we analyzed data from different studies in Germany and grouped ESBL-producing E. coli from different sources and human cases into subtypes based on their phenotypic and genotypic characteristics (ESBL-genotype, E. coli phylogenetic group and phenotypic antimicrobial resistance pattern). Then, a source attribution model was developed in order to attribute the human cases t

SUBMITTER: Perestrelo S 

PROVIDER: S-EPMC9286285 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature