"The ubiquitin ligase SIAH2 is a female-specific regulator of circadian rhythms and metabolism".

ABSTRACT: Circadian clocks enable organisms to predict and align their behaviors and physiologies to constant daily day-night environmental cycle. Because the ubiquitin ligase Siah2 has been identified as a potential regulator of circadian clock function in cultured cells, we have used SIAH2-deficient mice to examine its function in vivo. Our experiments demonstrate a striking and unexpected sexually dimorphic effect of SIAH2-deficiency on the regulation of rhythmically expressed genes in the liver. The absence of SIAH2 in females, but not in males, altered the expression of core circadian clock genes and drastically remodeled the rhythmic transcriptome in the liver by increasing the number of day-time expressed genes, and flipping the rhythmic expression from nighttime expressed genes to the daytim

SUBMITTER: Mekbib T 

PROVIDER: S-EPMC9286287 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature