Metabolomics in early life and the association with body composition at age 2 years.

ABSTRACT:

Background and objectives

Early life is a critical window for adiposity programming. Metabolic-profile in early life may reflect this programming and correlate with later life adiposity. We investigated if metabolic-profile at 3 months of age is predictive for body composition at 2 years and if there are differences between boys and girls and between infant feeding types.

Methods

In 318 healthy term-born infants, we determined body composition with skinfold measurements and abdominal ultrasound at 3 months and 2 years of age. High-throughput-metabolic-profiling was performed on 3-month-blood-samples. Using random-forest-machine-learning-models, we studied if the metabolic-profile at 3 months can predict body composition outcomes at 2 years of age.

Results

Plasma metab

SUBMITTER: van Beijsterveldt IALP 

PROVIDER: S-EPMC9286420 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature