Platelet-derived growth factor-BB and white matter hyperintensity burden in APOE4 carriers.

ABSTRACT:

Background

The apolipoprotein-e4 (APOE4) gene increases risk for developing late-onset Alzheimer's disease (AD) and has been linked to increased microvascular dysfunction, including pericyte degeneration and blood-brain barrier breakdown. Platelet-derived growth factor-BB (PDGF-BB) is a glycoprotein involved in blood-brain barrier and pericyte maintenance. Increased PDGF-BB levels have been reported in white matter in AD brain tissue. However, the association between circulating levels of PDGF-BB and cerebral white matter damage in older adults remains unknown.

Methods

Participants included community-dwelling older adults (age range 55-90 years, M = 73.1 years; SD =7.5; 61.0% male) from the Alzheimer's Disease Neuroimaging Initiative who underwent venipuncture

SUBMITTER: Kapoor A 

PROVIDER: S-EPMC9286493 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature