Magnetically steerable bacterial microrobots moving in 3D biological matrices for stimuli-responsive cargo delivery.

ABSTRACT: Bacterial biohybrids, composed of self-propelling bacteria carrying micro/nanoscale materials, can deliver their payload to specific regions under magnetic control, enabling additional frontiers in minimally invasive medicine. However, current bacterial biohybrid designs lack high-throughput and facile construction with favorable cargoes, thus underperforming in terms of propulsion, payload efficiency, tissue penetration, and spatiotemporal operation. Here, we report magnetically controlled bacterial biohybrids for targeted localization and multistimuli-responsive drug release in three-dimensional (3D) biological matrices. Magnetic nanoparticles and nanoliposomes loaded with photothermal agents and chemotherapeutic molecules were integrated onto Escherichia coli with ~90% efficiency

SUBMITTER: Akolpoglu MB 

PROVIDER: S-EPMC9286503 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature