Development and application of a pediatric mechanistic kidney model.

ABSTRACT: Pediatric physiologically-based pharmacokinetic (P-PBPK) models have been used to predict age related changes in the pharmacokinetics (PKs) of renally cleared drugs mainly in relation to changes in glomerular filtration rate. With emerging data on ontogeny of renal transporters, mechanistic models of renal clearance accounting for the role of active and passive secretion should be developed and evaluated. Data on age-related physiological changes and ontogeny of renal transporters were applied into a mechanistic kidney within a P-PBPK model. Plasma concentration-time profile and PK parameters of cimetidine, ciprofloxacin, metformin, tenofovir, and zidovudine were predicted in subjects aged 1 day to 18 years. The predicted and observed plasma concentration-time profiles and PK parameters we

SUBMITTER: Salem F 

PROVIDER: S-EPMC9286721 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature