Brain-wide screen of prelimbic cortex inputs reveals a functional shift during early fear memory consolidation.

ABSTRACT: Memory formation and storage rely on multiple interconnected brain areas, the contribution of which varies during memory consolidation. The medial prefrontal cortex, in particular the prelimbic cortex (PL), was traditionally found to be involved in remote memory storage, but recent evidence points toward its implication in early consolidation as well. Nevertheless, the inputs to the PL governing these dynamics remain unknown. Here, we first performed a brain-wide, rabies-based retrograde tracing screen of PL engram cells activated during contextual fear memory formation in male mice to identify relevant PL input regions. Next, we assessed the specific activity pattern of these inputs across different phases of memory consolidation, from fear memory encoding to recent and remote memory reca

SUBMITTER: Dixsaut L 

PROVIDER: S-EPMC9286739 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature