Proteomic analysis identified potential age-associated prognostic biomarkers in pneumonia-derived paediatric sepsis.

ABSTRACT:

Purpose

Our aim was to investigate the age-associated plasma protein profiles in pneumonia-derived sepsis between infants and toddlers and identify potential age-adapted prognostic markers for poor outcome of pneumonia-derived pediatric sepsis.

Experimental design

A nested case-control study strategy was applied. The plasma proteomes of pneumonia-derived pediatric septic patients with different outcomes between infants and toddlers were respectively analysed compared to their age-matched controls.

Results

Compared to toddlers, pneumonia-derived sepsis in infants was characterized by increased upregulation of protein processing in the ER, proteasome and antigen processing and presentation; and reduced downregulation in complement and coagulation cascades and cholestero

SUBMITTER: Luo T 

PROVIDER: S-EPMC9286787 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature