Serum levels of VCAM-1 are associated with survival in patients treated with nivolumab for NSCLC.

ABSTRACT:

Background

High circulating levels of cellular adhesion molecules (CAMs) in non-small cell lung cancer (NSCLC) have been supposed to act as a negative prognostic factor. Here, we explored the predictive role of pre-treatment levels of CAMs in previously treated patients receiving nivolumab for NSCLC.

Materials and methods

Seventy one patients with advanced NSCLC, treated with nivolumab at the dose of 3 mg/kg every 14 days, were enrolled. Maximum follow-up time was 3 years. Serum levels of Vascular Cell Adhesion Molecule-1 (VCAM-1) and Intracellular Adhesion Molecule-1 (ICAM-1) were measured at baseline and before each nivolumab administration. Endpoints of the study were a composite outcome of survival ≥2 years or absence of disease progression at the end of the follow-up, a

SUBMITTER: Carbone F 

PROVIDER: S-EPMC9286788 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature