Common Pathogenetic Mechanisms Underlying Aging and Tumor and Means of Interventions.

ABSTRACT: Recently, there has been an increase in the incidence of malignant tumors among the older population. Moreover, there is an association between aging and cancer. During the process of senescence, the human body suffers from a series of imbalances, which have been shown to further accelerate aging, trigger tumorigenesis, and facilitate cancer progression. Therefore, exploring the junctions of aging and cancer and searching for novel methods to restore the junctions is of great importance to intervene against aging-related cancers. In this review, we have identified the underlying pathogenetic mechanisms of aging-related cancers by comparing alterations in the human body caused by aging and the factors that trigger cancers. We found that the common mechanisms of aging and cancer include cell

SUBMITTER: Shen W 

PROVIDER: S-EPMC9286910 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature