Light-induced asymmetries in embryonic retinal gene expression are mediated by the vascular system and extracellular matrix.

ABSTRACT: Left-right asymmetries in the nervous system (lateralisation) influence a broad range of behaviours, from social responses to navigation and language. The role and pathways of endogenous and environmental mechanisms in the ontogeny of lateralisation remains to be established. The domestic chick is a model of both endogenous and experience-induced lateralisation driven by light exposure. Following the endogenous rightward rotation of the embryo, the asymmetrical position in the egg results in a greater exposure of the right eye to environmental light. To identify the genetic pathways activated by asymmetric light stimulation, and their time course, we exposed embryos to different light regimes: darkness, 6 h of light and 24 h of light. We used RNA-seq to compare gene expression in the right

SUBMITTER: Versace E 

PROVIDER: S-EPMC9287303 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature