Theoretical studies on RNA recognition by Musashi 1 RNA-binding protein.

ABSTRACT: The Musashi (MSI) family of RNA-binding proteins, comprising the two homologs Musashi-1 (MSI1) and Musashi-2 (MSI2), typically regulates translation and is involved in cell proliferation and tumorigenesis. MSI proteins contain two ribonucleoprotein-like RNA-binding domains, RBD1 and RBD2, that bind single-stranded RNA motifs with a central UAG trinucleotide with high affinity and specificity. The finding that MSI also promotes the replication of Zika virus, a neurotropic Flavivirus, has triggered further investigations of the biochemical principles behind MSI-RNA interactions. However, a detailed molecular understanding of the specificity of MSI RBD1/2 interaction with RNA is still missing. Here, we performed computational studies of MSI1-RNA association complexes, investigating different

SUBMITTER: Darai N 

PROVIDER: S-EPMC9287312 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature