Ontology highlight
ABSTRACT:
SUBMITTER: Darai N
PROVIDER: S-EPMC9287312 | biostudies-literature | 2022 Jul
REPOSITORIES: biostudies-literature
Darai Nitchakan N Mahalapbutr Panupong P Wolschann Peter P Lee Vannajan Sanghiran VS Wolfinger Michael T MT Rungrotmongkol Thanyada T
Scientific reports 20220715 1
The Musashi (MSI) family of RNA-binding proteins, comprising the two homologs Musashi-1 (MSI1) and Musashi-2 (MSI2), typically regulates translation and is involved in cell proliferation and tumorigenesis. MSI proteins contain two ribonucleoprotein-like RNA-binding domains, RBD1 and RBD2, that bind single-stranded RNA motifs with a central UAG trinucleotide with high affinity and specificity. The finding that MSI also promotes the replication of Zika virus, a neurotropic Flavivirus, has triggere ...[more]