Nox4 promotes endothelial differentiation through chromatin remodeling.

ABSTRACT:

Rationale

Nox4 is a constitutively active NADPH oxidase that constantly produces low levels of H₂O₂. Thereby, Nox4 contributes to cell homeostasis and long-term processes, such as differentiation. The high expression of Nox4 seen in endothelial cells contrasts with the low abundance of Nox4 in stem cells, which are accordingly characterized by low levels of H₂O₂. We hypothesize that Nox4 is a major contributor to endothelial differentiation, is induced during the process of differentiation, and facilitates homeostasis of the resulting endothelial cells.

Objective

To determine the role of No×4 in differentiation of murine inducible pluripotent stem cells (miPSC) into endothelial cells (ECs).

Methods and results

miPSC, generat

SUBMITTER: Hahner F 

PROVIDER: S-EPMC9287364 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature