Prophylactic furosemide to prevent transfusion-associated circulatory overload: a randomized controlled study in rats.

ABSTRACT: Transfusion-associated circulatory overload (TACO) is the leading cause of transfusion related morbidity and mortality. The only treatment is empirical use of furosemide. Our aim was to investigate if furosemide can prevent TACO. A randomized controlled trial was performed using a previously validated two-hit rat model for TACO. Volume incompliance was induced (first hit) in anemic, anesthetized Lewis rats. Rats were randomized to placebo, low-dose (5 mg kg^-1) or high-dose (15 mg kg^-1) furosemide-administered prior to transfusion (second-hit) and divided over two doses. Primary outcome was change in left-ventricular end-diastolic pressure (∆LVEDP) pre- compared to post-transfusion. Secondary outcomes included changes in preload, afterload, contractility and systemic v

SUBMITTER: Klanderman RB 

PROVIDER: S-EPMC9287390 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature