MIL-125-based nanocarrier decorated with Palladium complex for targeted drug delivery.

ABSTRACT: The aim of this work was to provide a novel approach to designing and synthesizing a nanocomposite with significant biocompatibility, biodegradability, and stability in biological microenvironments. Hence, the porous ultra-low-density materials, metal-organic frameworks (MOFs), have been considered and the MIL-125(Ti) has been chosen due to its distinctive characteristics such as great biocompatibility and good biodegradability immobilized on the surface of the reduced graphene oxide (rGO). Based on the results, the presence of transition metal complexes next to the drug not only can reinforce the stability of the drug on the structure by preparing π-π interaction between ligands and the drug but also can enhance the efficiency of the drug by preventing the spontaneous release. The effect

SUBMITTER: Bagherzadeh M 

PROVIDER: S-EPMC9287414 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature