Oncogenic BRAF induces whole-genome doubling through suppression of cytokinesis.

ABSTRACT: Melanomas and other solid tumors commonly have increased ploidy, with near-tetraploid karyotypes being most frequently observed. Such karyotypes have been shown to arise through whole-genome doubling events that occur during early stages of tumor progression. The generation of tetraploid cells via whole-genome doubling is proposed to allow nascent tumor cells the ability to sample various pro-tumorigenic genomic configurations while avoiding the negative consequences that chromosomal gains or losses have in diploid cells. Whereas a high prevalence of whole-genome doubling events has been established, the means by which whole-genome doubling arises is unclear. Here, we find that BRAF^V600E, the most common mutation in melanomas, can induce whole-genome doubling via cytokinesis fai

SUBMITTER: Darp R 

PROVIDER: S-EPMC9287415 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature