Fast regulation of the NF-κB signalling pathway in human skeletal muscle revealed by high-intensity exercise and ischaemia at exhaustion: Role of oxygenation and metabolite accumulation.

ABSTRACT: The NF-κB signalling pathway plays a critical role in inflammation, immunity, cell proliferation, apoptosis, and muscle metabolism. NF-κB is activated by extracellular signals and intracellular changes in Ca²⁺, P_i, H⁺, metabolites and reactive oxygen and nitrogen species (RONS). However, it remains unknown how NF-κB signalling is activated during exercise and how metabolite accumulation and PO₂ influence this process. Eleven active men performed incremental exercise to exhaustion (IE) in normoxia and hypoxia (P_IO₂:73 mmHg). Immediately after IE, the circulation of one leg was instantaneously occluded (300 mmHg). Muscle biopsies from m. vastus lateralis were taken before (Pre), and 10s (Post, occluded leg) and 60s after exerc

SUBMITTER: Gallego-Selles A 

PROVIDER: S-EPMC9287614 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature