Fusobacterium is enriched in oral cancer and promotes induction of programmed death-ligand 1 (PD-L1).

ABSTRACT: Recently, increased number of studies have demonstrated a relationship between the oral microbiome and development of head and neck cancer, however, there are few studies to investigate the role of oral bacteria in the context of the tumor microenvironment in a single head and neck subsite. Here, paired tumor and adjacent normal tissues from thirty-seven oral tongue squamous cell carcinoma (SCC) patients were subjected to 16S rRNA gene sequencing and whole exome sequencing (WES), in addition to RNA sequencing for tumor samples. We observed that Fusobacterium was significantly enriched in oral tongue cancer and that Rothia and Streptococcus were enriched in adjacent normal tissues. A decrease in alpha diversity was found in tumor when compared to adjacent normal tissues. While increased Fus

SUBMITTER: Michikawa C 

PROVIDER: S-EPMC9287628 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature