Analysis of copy number alterations in bladder cancer stem cells revealed a prognostic role of LRP1B.

ABSTRACT:

Purpose

Bladder cancer is the most common malignancy of the urinary tract and one of the most prevalent cancers worldwide. It represents a spectrum of diseases, from recurrent non-invasive tumors (NMIBCs) managed chronically, to muscle infiltrating and advanced-stage disease (MIBC) that requires multimodal and invasive treatment. Multiple studies have underlined the complexity of bladder tumors genome, highlighting many specific genetic lesions and genome-wide occurrences of copy-number alterations (CNAs). In this study, we analyzed CNAs of selected genes in our cohorts of cancer stem cells (CSCs) and in The Cancer Genome Atlas (TCGA-BLCA) cohort with the aim to correlate their frequency with patients' prognosis.

Methods

CNAs have been verified on our array-CGH data previous

SUBMITTER: Conconi D 

PROVIDER: S-EPMC9287687 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature