PH-sensitive packaging of cationic particles by an anionic block copolymer shell.

ABSTRACT: Cationic non-viral vectors show great potential to introduce genetic material into cells, due to their ability to transport large amounts of genetic material and their high synthetic versatility. However, designing materials that are effective without showing toxic effects or undergoing non-specific interactions when applied systemically remains a challenge. The introduction of shielding polymers such as polyethylene glycol (PEG) can enhance biocompatibility and circulation time, however, often impairs transfection efficiency. Herein, a multicomponent polymer system is introduced, based on cationic and hydrophobic particles (P(nBMA₄₆-co-MMA₄₇-co-DMAEMA₉₀), (PBMD)) with high delivery performance and a pH-responsive block copolymer (poly((N-acryloylmorpholine

SUBMITTER: Solomun JI 

PROVIDER: S-EPMC9287721 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature