Modularity of RBC hitchhiking with polymeric nanoparticles: testing the limits of non-covalent adsorption.

ABSTRACT: Red blood cell (RBC) hitchhiking has great potential in enhancing drug therapy, by improving targeting and reducing rapid clearance of nanoparticles (NPs). However, to improve the potential for clinical translation of RBC hitchhiking, a more thorough understanding of the RBC-NP interface is needed. Here, we evaluate the effects of NP surface parameters on the success and biocompatibility of NP adsorption to extracted RBCs from various species. Major differences in RBC characteristics between rabbit, mouse and human were proven to significantly impact NP adsorption outcomes. Additionally, the effects of NP design parameters, including NP hydrophobicity, zeta potential, surfactant concentration and drug encapsulation, on RBC hitchhiking are investigated. Our studies demonstrate the importanc

SUBMITTER: Lenders V 

PROVIDER: S-EPMC9287723 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature