Proton export upregulates aerobic glycolysis.

ABSTRACT:

Introduction

Aggressive cancers commonly ferment glucose to lactic acid at high rates, even in the presence of oxygen. This is known as aerobic glycolysis, or the "Warburg Effect." It is widely assumed that this is a consequence of the upregulation of glycolytic enzymes. Oncogenic drivers can increase the expression of most proteins in the glycolytic pathway, including the terminal step of exporting H⁺ equivalents from the cytoplasm. Proton exporters maintain an alkaline cytoplasmic pH, which can enhance all glycolytic enzyme activities, even in the absence of oncogene-related expression changes. Based on this observation, we hypothesized that increased uptake and fermentative metabolism of glucose could be driven by the expulsion of H⁺ equivalents from the ce

SUBMITTER: Russell S 

PROVIDER: S-EPMC9287933 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature