MiR-34a negatively regulates cell cycle factor Cdt2/DTL in HPV infected cervical cancer cells.

ABSTRACT: MicroRNAs have emerged as an important regulator of cell cycle and various other cellular processes. Aberration in microRNAs has been linked with development of several cancers and other diseases but still very little is known about the mechanism by which they regulate these cellular events. High risk human papilloma virus (HR HPV) is the causative agent of 99% of cervical cancer cases which attenuates multiple tumor suppressors and checkpoint factors of the host cell. The viral proteins also stabilize many oncogenic factors, including an essential cell cycle regulator Cdt2/DTL which in turn promotes cell transformation and proliferation. In this study, we report that a micro-RNA, miR-34a by suppressing HPV E6 protein, destabilizes Cdt2/DTL protein level in HPV infected cervical cancer cel

SUBMITTER: Singh G 

PROVIDER: S-EPMC9288023 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature