In Vivo Determination of the Human Corneal Elastic Modulus Using Vibrational Optical Coherence Tomography.

ABSTRACT:

Purpose

To determine the in vivo elastic modulus of the human cornea using vibrational optical coherence tomography (VOCT).

Methods

Vibrational analysis coupled with optical coherence tomography (OCT) was used to obtain the resonant frequency (RF) and elastic modulus of corneal structural components. VOCT corneal thickness values were measured using OCT images and correlated with corneal thickness determined with Pentacam (Oculus, Wetzlar, Germany). Moduli were obtained at two locations: central cornea (CC) and inferior cornea (IC). Measurements were obtained with and without anesthetic eye drops to assess their effect on the modulus measurements.

Results

VOCT thickness values correlated positively (R2 = 0.97) and linearly (y = 1.039x-16.89) with those of Pentacam. Fi

SUBMITTER: Crespo MA 

PROVIDER: S-EPMC9288150 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature