A human tissue-based assay identifies a novel carrion blowfly strain for maggot debridement therapy.

ABSTRACT: Maggot debridement therapy (MDT) is a form of therapeutic wound treatment in which live fly larvae are used intentionally to debride necrotic tissues. MDT has been widely used to treat chronic wounds in humans or animals, such as diabetic foot ulcers. Larvae of a carrion blowfly, Lucilia sericata (green bottle fly), debride wounds by consuming necrotic tissue and removing pathogenic bacteria, promoting effective wound healing. Most medical L. sericata strains were initially collected from natural environments using animal meat as bait and reared on artificial protein-rich media or ground meat. It remains to be examined which strain would be more appropriate for MDT, whereas any method for evaluating the fly's therapeutic potential in humans has not been available. A feeding assay was devel

SUBMITTER: Yoshida T 

PROVIDER: S-EPMC9288425 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature