ATM rules neurodevelopment and glutamatergic transmission in the hippocampus but not in the cortex.

ABSTRACT: Interest in the function of ataxia-telangiectasia-mutated protein (ATM) is extensively growing as evidenced by preclinical studies that continuously link ATM with new intracellular pathways. Here, we exploited Atm^+/- and Atm^-/- mice and demonstrate that cognitive defects are rescued by the delivery of the antidepressant Fluoxetine (Fluox). Fluox increases levels of the chloride intruder NKCC1 exclusively at hippocampal level suggesting an ATM context-specificity. A deeper investigation of synaptic composition unveils increased Gluk-1 and Gluk-5 subunit-containing kainate receptors (KARs) levels in the hippocampus, but not in the cortex, of Atm^+/- and Atm^-/- mice. Analysis of postsynaptic fractions and confocal studies indicates that KARs are pres

SUBMITTER: Focchi E 

PROVIDER: S-EPMC9288428 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature