Process optimization for the rapid conversion of calcite into hydroxyapatite microspheres for chromatographic applications

ABSTRACT: Microsphere hydroxyapatite (HAp) is widely used in various biomedical and chromatographic applications. The work described in this manuscript focuses on a dissolution precipitation method for production of HAp microspheres. This method overcomes certain drawbacks of conventional preparation methods used for HAp preparation, which produce polydisperse particles and are time-consuming and expensive. In the present work, the calcium carbonate (calcite) particles were directly and rapidly converted into HAp microspheres using an inexpensive dissolution precipitation method. The effects of the reaction temperature, time, and mechanical stirring rates were studied, and the reaction parameters were optimized. As confirmed by the XRD studies, the higher reaction temperature and time promote comple

SUBMITTER: Ashokan A 

PROVIDER: S-EPMC9288468 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature