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Pharmacological targeting of the tumor-immune symbiosis in glioblastoma.

ABSTRACT: Glioblastoma (GBM) is the most common and highly lethal form of primary brain tumor in adults. The median survival of GBM patients is approximately 14-16 months despite multimodal therapies. Emerging evidence has substantiated the critical role of symbiotic interactions between GBM cells and noncancerous immune cells (e.g., myeloid cells and T cells) in regulating tumor progression and therapy resistance. Approaches to target the tumor-immune symbiosis have emerged as a promising therapeutic strategy for GBM. Here, we review the recent developments for pharmacological targeting of the GBM-immune symbiosis and highlight the role of such strategies to improve the effectiveness of immunotherapies in GBM.

SUBMITTER: Pang L

PROVIDER: S-EPMC9288491 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature

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Pharmacological targeting of the tumor-immune symbiosis in glioblastoma.

Pang Lizhi L Khan Fatima F Dunterman Madeline M Chen Peiwen P

Trends in pharmacological sciences 20220507 8

Glioblastoma (GBM) is the most common and highly lethal form of primary brain tumor in adults. The median survival of GBM patients is approximately 14-16 months despite multimodal therapies. Emerging evidence has substantiated the critical role of symbiotic interactions between GBM cells and noncancerous immune cells (e.g., myeloid cells and T cells) in regulating tumor progression and therapy resistance. Approaches to target the tumor-immune symbiosis have emerged as a promising therapeutic str ...[more]

PMID: 35534356

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