RASGRF1 Fusions Activate Oncogenic RAS Signaling and Confer Sensitivity to MEK Inhibition.

ABSTRACT:

Purpose

The identification of actionable oncogenic alterations has enabled targeted therapeutic strategies for subsets of patients with advanced malignancies, including lung adenocarcinoma (LUAD). We sought to assess the frequency of known drivers and identify new candidate drivers in a cohort of LUAD from patients with minimal smoking history.

Experimental design

We performed genomic characterization of 103 LUADs from patients with ≤10 pack-year smoking history. Tumors were subjected to targeted molecular profiling and/or whole-exome sequencing and RNA sequencing in search of established and previously uncharacterized candidate drivers.

Results

We identified an established oncogenic driver in 98 of 103 tumors (95%). From one tumor lacking a known driver, we identifie

SUBMITTER: Hunihan L 

PROVIDER: S-EPMC9288503 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature