The Feasibility of Implementing Targeted SEDation in Mechanically Ventilated Emergency Department Patients: The ED-SED Pilot Trial.

ABSTRACT:

Objectives

Deep sedation in the emergency department (ED) is common, increases deep sedation in the ICU, and is negatively associated with outcome. Limiting ED deep sedation may, therefore, be a high-yield intervention to improve outcome. However, the feasibility of conducting an adequately powered ED-based clinical sedation trial is unknown. Our objectives were to assess trial feasibility in terms of: 1) recruitment, 2) protocol implementation and practice change, and 3) safety. Patient-centered clinical outcomes were assessed to better plan for a future large-scale clinical trial.

Design

Pragmatic, multicenter ( n = 3), prospective before-after pilot and feasibility trial.

Setting

The ED and ICUs at three medical centers.

Patients

Consecutive, adult mechanica

SUBMITTER: Fuller BM 

PROVIDER: S-EPMC9288529 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature