The effect of iron dextran on vitamin D3 metabolism in SD rats

ABSTRACT:

Background

Iron and vitamin D (VD) is essential to health. Previous studies have shown that iron homeostasis has a potential effect on VD metabolism, but the mechanism is not fully understood.

Objectives

To explore the relationship between VD metabolism and iron metabolism, as well as the regulatory mechanism of iron on VD metabolism.

Methods

40 male rats were fed adaptively for 7 days and randomly divided into control (C, n = 6 normal diet) group and model (M, n = 24 iron deficient diet) by simple randomization, the latter was used to establish iron deficiency anemia (IDA) model. After 6 weeks of feeding, the M group was randomly divided into: iron deficiency group (DFe), low iron group (LFe), medium iron group (MFe) and high iron group (HFe) by block randomizat

SUBMITTER: Qiu F 

PROVIDER: S-EPMC9288701 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature