Inflammasome activation in end-stage heart failure-associated atrial fibrillation.

ABSTRACT:

Aims

Inflammatory pathways are increasingly recognized as an important factor in the pathophysiology of both heart failure (HF) and atrial fibrillation (AF). However, there is no data about inflammation-related histological and molecular alterations in HF-associated AF. The objective of our study was to investigate inflammatory pathways and fibrosis in end-stage HF-associated AF.

Methods and results

Left atrial samples of 24 male patients with end stage ischemic HF undergoing heart transplantation were analysed. Twelve patients suffered from sustained AF while the others had no documented AF. The expression of inflammasome sensors and their downstream signalling were investigated by Western blot. No differences were observed in the expression of inflammasome sensors between

SUBMITTER: Kugler S 

PROVIDER: S-EPMC9288748 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature