Sex differences in efficacy of pharmacological therapies in heart failure with reduced ejection fraction: a meta-analysis.

ABSTRACT:

Aims

Recent studies have suggested potential sex differences in treatment response to pharmacological therapies in heart failure (HF). We performed a systematic review and meta-analysis of studies comparing treatment effects between men and women with HF and reduced ejection fraction (HFrEF) using established guideline-directed medical therapy and other emerging pharmacological treatments.

Methods and results

Systematic search was performed on PubMed, Embase, and Cochrane Library for randomized controlled trials published in 1990-2021. Outcomes were all-cause mortality and combined outcome of all-cause mortality and/or hospitalization for HF. Of 618 articles identified, 25 articles and 100 213 patients (mean age 62 ± 1.7 years, women 23.1%, mean left ventricular ejection fra

SUBMITTER: Danielson C 

PROVIDER: S-EPMC9288771 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature