The association between cardiac involvement and long-term clinical outcomes in patients with Duchenne muscular dystrophy.

ABSTRACT:

Aims

Despite advances in contemporary cardiopulmonary therapies, cardiomyopathy remains the leading cause of death in patients with Duchenne muscular dystrophy (DMD). Also, the long-term clinical outcomes of patients with DMD and cardiomyopathy is unknown. This study investigated long-term clinical outcomes and their associated factors in patients with late-stage DMD.

Methods and results

A total of 116 patients with late-stage DMD (age > 15 years) were enrolled in this retrospective study. All enrolled patients were followed up at a single tertiary referral hospital. LV systolic dysfunction was dichotomously defined as reduced [left ventricular ejection fraction (LVEF) ≤ 40%] vs. preserved [>40%] based on the initial echocardiographic result. The primary endpoint was all-cau

SUBMITTER: Cha JJ 

PROVIDER: S-EPMC9288783 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature