Multivariable prognostic model for heart failure in Chinese Han population-based setting.

ABSTRACT:

Aims

The prognosis of heart failure (HF) depends on genetic predisposition, and recent studies have shown that impaired autophagy is involved in HF. This study was aimed to construct a prognostic model combining polygenetic background based on the autophagy pathway and other traditional risk factors (TRF) of HF prognosis.

Methods and results

Via re-analysing the transcriptomic data of 50 failing and 14 non-failing donors, differentially expressed autophagy-related genes (ARGs) were chosen for further comparison and analysis with whole exome sequencing and follow-up data of 1000 HF patients. By searching from reported articles, prognosis-related polymorphisms were identified. ARGs and prognosis-related polymorphisms were used to develop genetic risk score (GRS) and genetic ri

SUBMITTER: Huang M 

PROVIDER: S-EPMC9288793 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature