Multimorbidity, guideline-directed medical therapies, and associated outcomes among hospitalized heart failure patients.

ABSTRACT:

Aims

Multimorbidity is common among heart failure (HF) patients and may attenuate guideline-directed medical therapy (GDMT). Multimorbid patients are under-represented in clinical trials; therefore, the effect of multimorbidity clustering on the prognosis of HF patients remains unknown. We evaluated the prevalence of multimorbidity clusters among consecutively registered hospitalized HF patients and assessed whether GDMT attenuated outcomes.

Methods and results

We examined 1924 hospitalized HF patients with reduced left ventricular ejection fraction (<50%) in a multicentre registry (West Tokyo HF Registry: WET-HF). Ten comorbid conditions in the WET-HF were abstracted: coronary artery disease, atrial fibrillation, stroke, anaemia, chronic obstructive pulmonary disease, renal

SUBMITTER: Takeuchi S 

PROVIDER: S-EPMC9288806 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature