Aberrant static and dynamic functional network connectivity in heart failure with preserved ejection fraction.

ABSTRACT:

Aims

Heart failure may lead to brain functional alterations related to cognitive impairment. This study aimed to detect alterations of static functional network connectivity (FNC) and dynamic FNC in heart failure with preserved ejection fraction (HFpEF) and to estimate the association between the altered FNC and clinical features related to HFpEF.

Methods and results

The clinical and resting-state functional magnetic resonance imaging (fMRI) data of HFpEF patients (n = 35) and healthy controls (HCs) (n = 35) were acquired at baseline. Resting-state networks (RSNs) were established based on independent component analysis (ICA) and FNC analyses were performed. The associations between the FNC abnormalities and clinical features related to HFpEF were analysed. Compared with HCs

SUBMITTER: Jiang L 

PROVIDER: S-EPMC9288811 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature