Hypokinetic hypertrophic cardiomyopathy: clinical phenotype, genetics, and prognosis.

ABSTRACT:

Aims

To describe the phenotype, genetics, and events associated with the development of hypertrophic cardiomyopathy (HCM) with reduced ventricular function (HCMr). Heart failure in HCM is usually associated with preserved ejection fraction, yet some HCM patients develop impaired systolic function that is associated with worse outcomes.

Methods and results

Our registry included 1328 HCM patients from two centres in Spain and Israel. Patients with normal baseline ventricular function were matched, and a competing-risk analysis was performed to find factors associated with HCMr development. Patient records were reviewed to recognize clinically significant events that occurred closely before the development of HCMr. Genetic data were collected in patients with HCMr. A composite

SUBMITTER: Wasserstrum Y 

PROVIDER: S-EPMC9288812 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature