Reconstitution of Membrane Proteins into Platforms Suitable for Biophysical and Structural Analyses.

ABSTRACT: Integral membrane proteins have historically been challenging targets for biophysical research due to their low solubility in aqueous solution. Their importance for chemical and electrical signaling between cells, however, makes them fascinating targets for investigators interested in the regulation of cellular and physiological processes. Since membrane proteins shunt the barrier imposed by the cell membrane, they also serve as entry points for drugs, adding pharmaceutical research and development to the interests. In recent years, detailed understanding of membrane protein function has significantly increased due to high-resolution structural information obtained from single-particle cryo-EM, X-ray crystallography, and NMR. In order to further advance our mechanistic understanding on mem

SUBMITTER: Schmidpeter PAM 

PROVIDER: S-EPMC9288841 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature