EGFL7 expression profile in IDH-wildtype glioblastomas is associated with poor patient outcome.

ABSTRACT:

Background

Despite the advances in glioblastoma (GBM) treatment, the average life span of patients is 14 months. Therefore, it is urgent to identity biomarkers of prognosis, treatment response, or development of novel treatment strategies. We previously described the association of high epidermal growth factor-like domain multiple 7 (EGFL7) expression and unfavorable outcome of pilocytic astrocytoma patients. The present study aims to analyze the prognostic potential of EGFL7 in GBM isocitrate dehydrogenase (IDH)-wildtype, using immunohistochemistry and in silico approaches.

Methods

Spearman's correlation analysis of The Cancer Genome Atlas RNA sequencing data was performed. The genes strongly correlated to EGFL7 expression were submitted to enrichment gene ontology and Kyot

SUBMITTER: da Costa BHB 

PROVIDER: S-EPMC9288890 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature